Busting the billion-dollar myth: how to slash the cost of drug development

A new approach to distributing pharmaceuticals in Egypt could become the blueprint for providing cutting-edge medicines to the poor. The approach, developed to fight Hep. C, capitalizes on local networks and involves negotiating lower prices with drug companies.

One-pill-a-day generic AIDS drugs for poor countries are hard to make because each ingredient is patented by a different pharmaceutical company. The Patent Pool provides a way for companies to donate their intellectual property safely.

While critics argue that Naloxone isn't safe for over-the-counter use, some cities have found success distributing Naloxone to community members to help save lives of addicts who overdose. Naloxone can be administered to help those overdosing survive and jump-start the withdrawal process.

Prescription drugs are greatly polluting the national water supply, causing researchers to begin looking for a method to better filter water and dispose of unused medicine.

In the developing world, intestinal worms stunt physical and mental growth, drain energy, and can inhibit school work for children. Deworm the World is a global campaign that lobbied the Delhi government to regularly distribute deworming pills to school children. The benefits decrease student absenteeism and increase cost-saving measures.

Often it is faster and easier to harvest molecules for medical purposes from nature than to make them in a laboratory. A scientist is looking for cancer-fighting molecules in coral and sponges in the tropical Pacific.

Once-a-day generic AIDS drugs for poor countries are hard to make because each ingredient is patented by a different pharmaceutical company. The Patent Pool provides a way for companies to donate their intellectual property safely.

One in five seniors reports cutting back on basics like food or heat to afford prescription drugs - for many, cutting back on medicine led to faster health declines, increased hospitalizations and premature death. Sirum, a new nonprofit, was designed to make it easy for institutions to donate medicines with the assurance that they would be safely transported and dispensed to people who needed them.

For decades, the only good option for alcoholics seeking recovery was an abstinence-based 12-step program called Alcoholics Anonymous. John David Sinclair, an American neuroscientist, has developed a new method, where an alcoholic takes naltrexone one hour before drinking. The naltrexone blocks the brain's opioid receptors and prevents an alcoholics strong synaptic reward response from occurring, which allows their craving for alcohol to eventually subside.

Despite significant increases in funding and advances in biomedical research, the rates of new treatments and drugs for illnesses that reach the market every year have plummeted. A group called the Myelin Repair Foundation, along with several other foundations, uses an intensely goal-directed and collaborative method to tackle the bottleneck.